Merck, J4144-100UG, Jo-1 human

General description
Jo-1, or histidyl-transfer ribonucleic acid synthetase, is a homodimeric enzyme that catalyzes the coupling of histidine to its specific transfer RNA (tRNA), prior to transport of histidine to the ribosome, and subsequent incorporation of histidine into polypeptide chains. Jo-1 has been associated with various autoimmune disorders, such as polymyositis and dermatomyositis, and T-cell mediated autoimmunity.
Biochem/physiol Actions
The anti-Jo-1 antibody has been associated with an increased frequency of interstitial pulmonary disease in polymyositis/dermatomyositis patients.
Used in the immunoassay for antibodies to Jo-1.
Physical form
Solution in 6 M urea, 500 mM sodium chloride, 10 mM Tris HCl buffer, pH 8.0.