Merck, K1751-100G, Ketoprofen

General description
Ketoprofen belongs to the class of 2-arylpropionic acid.
Application
Ketoprofen has been used:
as sample to analyse the effects of long storage period by chromatographic and microscopic techniques
as a nonselective COX inhibitor to inject subcutaneously in rats to study its effect on stress/methamphetamine hydrochloride-induced changes in occludin, claudin-5 and COX-2 protein immunoreactivity, truncation of β-dystroglycan, brain water content and fluorescein isothiocyanate-dextran extravasation
in phosphate buffer to study its ability to inhibit heat-induced denaturation of albumin

Biochem/physiol Actions
It serves as an efficient drug to treat ankylosing spondylitis, rheumatoid arthritis and osteoarthritis. It also has antipyretic and analgesic effects. Ketoprofen prevents the action of prostaglandin synthetase.
Non-steroidal anti-inflammatory compound that is selective for COX-1.
Features and Benefits
This compound was developed by Bayer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.