Merck, M3895-500MG, Mucin from bovine submaxillary glands

General description
Neuraminidase substrate.
Mucin from bovine submaxillary glands is encoded by two bovine submaxillary BSM genes. It is present in the saliva and interacts with air and food. Mucin comprises three major domains namely N- and C terminal and the glycosylated proline, threonine and serine (PTS domain) central domain. The sialic acid contributes to 30% of the molecular weight of mucin. The central domain has many tandem repeats.
Application
Mucin from bovine submaxillary glands has been used:
in the quantification of mucin
as a component of artificial tear solution
as a substrate for recombinant sialidase Gardnerella vaginalis
to investigate a galactose-specific lectin from the red marine alga Ptilota filicina
to study the characterization of a unique mucin-like glycoprotein secreted by a human endometrial adenocarcinoma cell line (Ishikawa)

Biochem/physiol Actions
Albuminoid substance in mucus which gives it its ropy consistency
Bovine submaxillary mucin (BSM) is thermally stable up to 85°C. The terminal domain regions are key for the adsorption functionality of mucin.
Other Notes
Similar to M 4503, but produced by Sigma.