Merck, P0878-5G, O-Phospho-L-serine

Application
O-Phospho-L-serine has been used:
for the expression, purification and phosphorylation of protein
to study its chemical shift
to spectroscopically determine its pKa values using Raman spectroscopy

Biochem/physiol Actions
O-Phospho-L-serine (L-SOP) is a molecule which resembles phosphatidylserine head group and it mediates partial inhibition of microglial phagocytosis of apoptotic cells. In zebrafish, L-SOP inhibits Müller glia proliferation and blocks cone cell regeneration in the light-damaged retina. In vivo, L-SOP acts as a substrate for CysM, a cysteine synthase from Mycobacterium tuberculosis.
Group III metabotropic glutamate receptor agonist (mGluR4, mGluR7, and mGluR8).