Merck, P3111-50ML, Protease from Bacillus sp.

Application
Protease is an enzyme used to break down proteins by hydrolyzing peptide bonds. Product P3111 is secreted from Bacillus sp.. It is a serine-type protease characterized by excellent performance at elevated temperature and pH. Product P3111 is extremely stable under harsh storage conditions, such as in the presence of sodium hypochlorite. Protease is used to degrade proteins, to study protease inhibitors and to study thermal inactivation kinetics.
Biochem/physiol Actions
Protease catabolizes proteins by hydrolysis of peptide bonds. Proteases are inactivated by serine active-site inhibitors, such as phenylmethylsulfonyl fluoride (PMSF) and diisopropylfluorophosphate. Proteases, secreted from Bacillus sp., typically have molecular weights ranging from 20,000 to 30,000. They are typically stabilized by Ca²⁺ and have high isoelectric points. It is highly soluble in detergents at a wide range of pH and temperatures.
Legal Information
A product of Novozyme Corp.
Savinase is a registered trademark of Novozymes Corp.