Merck, P9375-100G, 1,10-Phenanthroline monohydrate

General description
Phenanthroline is a heterocyclic organic compound, which forms complexes with metal ions. These complexes have wide applications in biochemistry, catalysis and analytical chemistry. It complexes with iron and is exploited as a redox indicator.
Application
1,10-Phenanthroline monohydrate has been used:
as an inhibitor of metalloproteinase (MMP) in MDA-MB-231 breast cancer cells
as a negative control in in situ zymography of mice heart samples
in in vitro resveratrol chelation and reducing activities assays to chelate iron

When complexed with copper, it possesses nuclease activity that has been used to study DNA-protein interactions.
Biochem/physiol Actions
Metalloprotease inhibitor; chelates iron, zinc and other divalent metals. Effective concentration 1-10 mM.