General description
Cytokines are small proteins secreted by immune cells that regulate immune responses, hematopoiesis, and lymphocyte development, including interleukins, interferons, and chemokines. Growth factors, which promote cell growth and proliferation, share structural and functional similarities with cytokines and act through specific receptors on target cells. Unlike hormones produced by specialized glands, both cytokines and growth factors can be secreted by various cell types, and their tightly regulated expression is crucial; dysregulation can lead to diseases such as infections, autoimmune disorders, and cancer. Research on these molecules is essential for understanding the immune system and developing therapeutic strategies, with non-human primates serving as important models due to their genetic similarity to humans.
Application
MILLIPLEX® Qualified assays undergo rigorous assay development, verification, and Quality Control testing to achieve optimal performance. Simultaneously analyze up to 48 analytes in non-human primate serum, plasma, and cell culture supernatants.
Analytes included: BCA-1, sCD137, CD40L, Eotaxin, sFASL, FGF-2, Fractalkine, G-CSF, GM-CSF, Granzyme A, Granzyme B, IFNα2, IFNγ, IL-1α, IL-1β, IL-1RA, IL-2, IL-4, IL-5, IL-6, IL-7, IL-8, IL-10, IL-12 (p70), IL-15, IL-16, IL-17A, IL-17E, IL-18, IL-21, IL-22, IL-23, IL-28A, IL-31, IL-33, IP-10, I-TAC, MCP-1, MIG, MIP-1α, MIP-1β, MIP-3α, Perforin, RANTES, TGFα, TNFα, TNFβ, VEGF-A
Note: RANTES cannot be plexed with other cytokines in this panel due to a required 1:100 dilution of plasma/serum samples. This premixed panel comes with a RANTES bead, so please plan your samples accordingly.
Assay Characteristics: Refer to kit protocol for assay cross-reactivity, sensitivity, precision, and accuracy.
Features and Benefits
Non-Human Primate Specific: Designed specifically for non-human primate samples, making it ideal for translational research.
Configurable Panel: Users can design their own multiplex kit by selecting from the available analytes.
Comprehensive Multiplexing: Simultaneous quantification of up to 48 analytes including cytokines, chemokines, and growth factors in a single assay.
Verified Dilution Guidelines: Includes specific instructions for analytes like RANTES and IL-8 to ensure optimal performance.
Trusted Technology: Utilizes Luminex® xMAP® technology, a gold standard in multiplex biomarker analysis.
Largest multiplex panel for non-human primates: This unmatched breadth empowers researchers to maximize data output from minimal sample volume, enabling comprehensive immune profiling in NHP models with unparalleled efficiency and sensitivity.
Legal Information
Luminex is a registered trademark of Luminex Corporation
MILLIPLEX is a registered trademark of Merck KGaA, Darmstadt, Germany
xMAP is a registered trademark of Luminex Corp
Disclaimer
For research use only. Not for use in diagnostic procedures.
Label License/Sticker for Assay Product:
By opening the packaging containing this Assay Product (which contains fluorescently labeled microsphere beads authorized by Luminex Corporation) or using this Assay Product in any manner, you are consenting and agreeing to be bound by the End User Terms and Conditions and the End User License Agreement available at http://support.diasorin.com/end-user-terms-and-conditions/. If you do not agree to all of the terms and conditions, you must promptly return this Assay Product for a full refund prior to using it in any manner.
