Merck, PZ0021-25MG, Tigecycline hydrate

General description
Tigecycline is used to treat complicated skin and skin structure infections (cSSSI) and complicated intraabdominal infections.
Application
TIGECYCLINE HYDRATE has been used:
for antibiotic susceptibility testing
to study its effects on multiple nonsmall cell lung cancer (NSCLC) cell lines
to evaluate its effects on the binding of fluoroquinolones to human serum albumin
as a standard to investigate the penetration of tigecycline into cornea, aqueous humor and vitreous humor

Biochem/physiol Actions
Tigecycline is a broad spectrum glycylcycline antibiotic.
Tigecycline is a broad spectrum glycylcycline antibiotic. Tigecycline is bacteriostatic, that inhibits protein synthesis by binding to the 30S ribosomal subunit of bacteria and thereby blocking entry of Aminoacyl-tRNA into the A site of the ribosome during prokaryotic translation. Tigecycline is active against resistant strains of gram-positive and gram-negative bacteria, avoiding the two most common mechanisms of resistance to the tetracycline antimicrobials: tetracycline efflux pump proteins and ribosomal protection proteins.
Other Notes
air sensitive