Merck, R3255-100MG, 13-cis-Retinoic acid

Application
13-cis-Retinoic acid has been used:
as a component of fresh media for LA-N-5 differentiation
to treat medulloblastoma cells for cell differentiation
to treat spheroids for generating time-lapse videos
to examine its head- deforming activity under light and dark conditions in Xenopus laevis

Biochem/physiol Actions
13-cis-Retinoic acid (RA) has anti-inflammatory and anti-tumor action. The action of RA is mediated through RAR-β and RAR-α receptors. RA attenuates iNOS expression and activity in cytokine-stimulated murine mesangial cells. It induces mitochondrial membrane permeability transition, observed as swelling and as a decrease in membrane potential, and stimulates the release of cytochrome c implicating mechanisms through the apoptosis pathway. These activities are reversed by EGTA and cyclosporin A. RA also increases MMP-1 protein expression partially via increased transcription.
Features and Benefits
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