Merck, RDD029-1KG, Guanidine thiocyanate

General description
Guanadine thiocyanate (GTC) is a chaotropic agent and strong denaturant that is used in research for protein degredation in vitro. This is useful for DNA or RNA isolation and purification. GTC is a key reagent for inactivation of endogenous DNases and RNase for molecular biology techniques used to isolate nucliec acids from tissues, cells, or viral genomes.
Application
Chaotropic agent and strong denaturant; solubilizes cells.
Guanidine thiocyanate is commonly used for research:

to denature proteins in cell lysis buffer
to isolate and purify RNA from cells and tissues
to extract DNA from cellular and viral genomes

Biochem/physiol Actions
Guanadine thiocyanate is strong protein denaturant commonly combinded with phenol to lyse tissues, cells, and proteins during RNA isolation assay.
Features and Benefits
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Controls moisture and powder remains free-flowing
Safer to handle and weigh out for routine use in lab
Eliminates clumps and maintains product moisture and quality attributes

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