Merck, SAB5702072-100UL, Anti-SDHB Antibody, clone 9S1A0, Rabbit Monoclonal

General description
Complex II of the respiratory chain, which is specifically involved in the oxidation of succinate, carries electrons from FADH to CoQ. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. The iron-sulfur subunit is highly conserved and contains three cysteine-rich clusters which may comprise the iron-sulfur centers of the enzyme. Sporadic and familial mutations in this gene result in paragangliomas and pheochromocytoma, and support a link between mitochondrial dysfunction and tumorigenesis. [provided by RefSeq, Jul 2008]
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 181-280 of human SDHB (P21912).
PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Application
WB