Description
Application
Fluvastatin sodium hydrate has been used:
to examine its effect on β -glucan-induced training on immunity
to investigate the effect of statins on the number of uncoupling protein 1 (UCP1)+ cells
to determine its effect on insulin degrading enzyme (IDE) secretion from astrocytes
to treat and study its effect on human umbilical vein endothelial cells (HUVECs) in vitro
Fluvastatin sodium hydrate has been used:
to test its anti-hepatitis C virus (HCV) activity
as a cholesterol inhibitor
to study its effects on β-glucan-induced monocyte immune training
Biochem/physiol Actions
Fluvastatin is a competitive inhibitor of hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase, the enzyme that catalyzes the conversion of HMG-CoA to mevalonic acid, the rate-limiting step in cholesterol biosynthesis. Fluvastatin is antilipemic and is used to reduce plasma cholesterol levels and prevent cardiovascular disease.
Fluvastatin has antifungal activity.
Features and Benefits
This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.