Merck, SML0341-25MG, Importazole

Application
Importazole has been used:
to inhibit importin-β and to elucidate the mechanism of enhanced nuclear localization of heat shock protein 70 (HSP70) by vaccinia-related kinase 3 (VRK3)
to treat COS?7 cells transfected with the expressing vectors of WT HNF4α , S78A, and S78D to study its effect
as a KPNB inhibitor to determine whether CREB-regulated co-activator 1 (CRTC1) would be escorted into the nucleus by the classical nuclear localizing sequence (NLS)- dependent machinery
as a functional inhibitor of Importin β in embryo treatment
as an importin inhibitor to treat the transfected H1299 cells to block nuclear translocation of phosphorylated p53-RS

Biochem/physiol Actions
Importazole is an inhibitor of importin-β transport receptors.
Importazole is an inhibitor of importin-β transport receptors. During interphase, the transport receptor importin-β carries cargoes into the nucleus, where RanGTP releases them. Importazole somehow disrupts the importin/RAN interaction. Importazole is selective among other transporters. Compounds are imported into, but not out of, cells.