Merck, SML0580-25MG, Nutlin-3a

Name: Nutlin-3a
Brand: Merck
SKU: SML0580-25MG

Size:25 mg, (-)-4-(4, 5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4, 5-dihydro-1H-imidazole-1-carbonyl)piperazin-2-one, (-)-Nutlin-3, 4-[[(4S, 5R)-4, 5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4, 5-dihydroimidazol-1-yl]carbonyl]piperazin-2-one, 4-[[(4S, 5R)-4, 5-Bis(4-chlorophenyl)-4, 5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-2-Piperazinone, Nutlin 3a, ≥98% (HPLC)

Available Catalog Numbers

SML0580-25MG SML0580-5MG

Catalog Number: SML0580-25MG

Pricing

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Category

Protein Crosslinkers

Pack Size25 mg

TagsChemistry & Biochemicals Chemical Biology Protein Degrader Building Blocks

CollectionsMerck Cell Culture Supplements & Reagents: Complete Solutions for Research & Bioproduction Merck Roche Life Science Products for PCR, RT‑PCR & Nucleic Acid Purification

Description

Application
Nutlin-3a has been used as a tumor suppressor p53(TP53) stabilizer and as an inhibitor of the mouse double minute 2 homolog (MDM2)–p53 interaction.
Biochem/physiol Actions
Nutlin-3a [(-)-Nutlin] is a more potent diastereoisomer of racemic MDM2 antagonist Nutlin-3. It was called enantiomer-a since it elutes as the first peak from chiral purification of racemic nutlin-3. Nutlin-3a is a potent inhibitor of MDM2 (mouse double minute 2) binding to p53 that induces the expression of p53 regulated genes, and shows potent antiproliferative activity in cells expressing functional p53. Nutlin-3a is 150 times more potent than Nutlin-3b.
Nutlin-3a [(-)-Nutlin] is a potent inhibitor of MDM2 (mouse double minute 2) binding to p53; Mdm2 antagonist.
Nutlin-3a is a potent nongenotoxic drug. It acts as a tumor suppressor p53 (TP53) activator and stabilizer.
Features and Benefits
This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Specifications

General

UNSPSC Code	12352200
PubChem Substance ID	329825564
NACRES	NA.77
Web Name Suffix Override	≥98% (HPLC), MDM2 inhibitor, powder
MDL number	MFCD14636430
SMILES string	O=C(N1CC(NCC1)=O)N2[C@H](C3=CC=C(Cl)C=C3)[C@H](C4=CC=C(Cl)C=C4)N=C2C5=CC=C(OC)C=C5OC(C)C
InChI key	BDUHCSBCVGXTJM-WUFINQPMSA-N
InChI	1S/C30H30Cl2N4O4/c1-18(2)40-25-16-23(39-3)12-13-24(25)29-34-27(19-4-8-21(31)9-5-19)28(20-6-10-22(32)11-7-20)36(29)30(38)35-15-14-33-26(37)17-35/h4-13,16,18,27-28H,14-15,17H2,1-3H3,(H,33,37)/t27-,28+/m0/s1
ligand	nutlin-3a
assay	≥98% (HPLC)
form	powder
optical activity	[α]/D -130 to -154° (c=0.5, CDCl3)
reaction suitability	reagent type: ligand
color	white to beige
solubility	DMSO: 5 mg/mL, clear
shipped in	wet ice
storage temp.	−20°C
Quality Level	100

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Merck, SML0580-25MG, Nutlin-3a

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