Merck, SML0729-1MG, BAM8-22 trifluoroacetate salt

Name: BAM8-22 trifluoroacetate salt
Brand: Merck
SKU: SML0729-1MG

Size:1 mg, BAM (8-22) trifluoroacetate salt, Bovine Adrenal Medulla 8-22 trifluoroacetate salt, Bovine adrenal medulla peptide (8-22) trifluoroacetate salt, L-Valyl-glycyl-L-arginyl-L-prolyl-L-α-glutamyl-L-tryptophyl-L-tryptophyl-L-methionyl-L-α-aspartyl-L-tyrosyl-L-glutaminyl-L-lysyl-L-arginyl-L-tyrosyl-glycine trifluoroacetate salt, VGRPEWWMDYQKRYG trifluoroacetate salt, Val-Gly-Arg-Pro-Glu-Trp-Trp-Met-Asp-Tyr-Gln-Lys-Arg-Tyr-Gly trifluoroacetate salt, ≥98% (HPLC)

Catalog Number: SML0729-1MG

Pricing

Send an RFQ.

View RFQ List

Category

Size Exclusion Resins

Pack Size1 mg

CollectionsMerck Cell Culture Supplements & Reagents: Complete Solutions for Research & Bioproduction Merck Roche Life Science Products for PCR, RT‑PCR & Nucleic Acid Purification

Description

Application
BAM8-22 trifluoroacetate salt has been used in the study to identify the functions of Mas-related gene (Mrg) C in the pathogenesis and treatment of bone cancer pain (BCP).
Biochem/physiol Actions
BAM8-22 is a selective agonist for the sensory neuron specific G-protein coupled receptors (SNSRs).
BAM8-22 is a selective agonist for the sensory neuron specific G-protein coupled receptors (SNSRs). BAM8-22 inhibits development of morphine tolerance in rats. BAM8-22 is inactive at opioid receptors. Also, BAM8–22 is a potent activator of Mas-related G-protein-coupled receptors (Mrgprs), MrgprC11 and hMrgprX1. BAM8-22 produces itch and nociceptive sensations in humans in a histamine-independent manner.
Bovine adrenal medulla 8-22 (BAM8-22), a 15-amino acid peptide, acts a cleavage product of proenkephalin A and the precursor of Leu- and Met-enkephalin in the adrenal medulla. It may also be used to treat pain. It blocks inflammatory pain, chemical pain and downregulates the expression of spinal c-fos gene in an opioid-independent manner. In mice, BAM8-22 diminishes bone cancer pain. It induces the expression of Mas-related G-protein-coupled receptor C (MrgC) in the spinal dorsal horn.

Specifications

General

UNSPSC Code	12352200
NACRES	NA.77
Web Name Suffix Override	≥98% (HPLC), G-protein coupled receptor agonist, powder
SMILES string	S(CC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H]7N(CCC7)C(=O)[C@@H](NC(=O)CNC(=O)[C@@H](N)C(C)C)CCCN\C(=N\[H])\N)CCC(=O)O)Cc5c6c([nH]c5)cccc6)Cc3c4c([nH]c3)cccc4)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccc(cc2)O)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H]
InChI	1S/C91H127N25O23S/c1-48(2)76(94)88(138)103-46-72(120)105-64(19-11-36-100-91(97)98)89(139)116-37-12-20-70(116)87(137)110-62(30-32-73(121)122)81(131)113-68(42-52-45-102-58-16-7-5-14-56(52)58)85(135)114-67(41-51-44-101-57-15-6-4-13-55(51)57)84(134)109-63(33-38-140-3)82(132)115-69(43-74(123)124)86(136)112-66(40-50-23-27-54(118)28-24-50)83(133)108-61(29-31-71(93)119)80(130)106-59(17-8-9-34-92)78(128)107-60(18-10-35-99-90(95)96)79(129)111-65(77(127)104-47-75(125)126)39-49-21-25-53(117)26-22-49/h4-7,13-16,21-28,44-45,48,59-70,76,101-102,117-118H,8-12,17-20,29-43,46-47,92,94H2,1-3H3,(H2,93,119)(H,103,138)(H,104,127)(H,105,120)(H,106,130)(H,107,128)(H,108,133)(H,109,134)(H,110,137)(H,111,129)(H,112,136)(H,113,131)(H,114,135)(H,115,132)(H,121,122)(H,123,124)(H,125,126)(H4,95,96,99)(H4,97,98,100)/t59-,60-,61-,62-,63-,64-,65-,66-,67-,68-,69-,70-,76-/m0/s1

Ordering

Notice

Unless otherwise stated, the minimum order amount is USD 1,000.
For orders below USD 1,000, an additional handling fee may apply, or we may arrange local delivery / local handover where available.
All quotations are subject to final confirmation, including product availability, lead time, batch information, shipping cost, and applicable export or handling requirements.
For quotation requests, please send an RFQ from website or contact:

[email protected]

Please send inquiries directly to us in the “To” field. Emails sent via BCC, mass mailing, or with unrelated recipients may be automatically filtered and will not be processed.

Merck, SML0729-1MG, BAM8-22 trifluoroacetate salt

Send an RFQ.

General

Notice

More from Merck.

Guanidinium chloride

Tris(hydroxymethyl)aminomethane hydrochloride

D-(+)-Glucose

Tri-n-butyl phosphate

More from Merck.

Guanidinium chloride

Tris(hydroxymethyl)aminomethane hydrochloride

D-(+)-Glucose

Tri-n-butyl phosphate