Merck, SML0964-25MG, KNK437

Application
KNK437 has been used:
as a heat shock factor 1 (HSF1) inhibitor to study its effects on the inhibition of viability and apoptosis activation in chemoresistant mice cells
as an HSF1 inhibitor to study its effects on viability and apoptosis of colorectal cancer cells
as a heat shock protein 70 (HSP70) inhibitor to study its effects on glutamine-induced HSP70 and inflammatory mediator release

Biochem/physiol Actions
KNK437 inhibits the accumulation of heat shock proteins (including hsp -27, -40, -70, -72 and -105). KNK437 inhibits thermotolerance in cells with greater potency than quercetin.
KNK437 is a heat shock protein inhibitor.
KNK437 is a benzylidene lactam compound.