Biochem/physiol ActionsBAY-876 is a potent, highly selective, cell-permeable inhibitor of glucose transporter GLUT1. It had an IC50 value of 2 nM in vitro and inhibited glucose uptake by Hela-MaTu cells with an IC50 value of 3.2 nM. BAY-876 was at least 130-fold selective for GLUT1 relative to GLUT2, GLUT3, GLUT4 and a panel of 18 kinases and 68 proteins. For full characterization details, please visit the
BAY-876 probe summary on the Structural Genomics Consortium (SGC) website.
BAY-588 is the negative control for the active probe, BAY-876. BAY-588 is available from Sigma. To learn more about and purchase BAY-588,
click here.
To learn about other SGC chemical probes for protein targets, visit
sigma.com/sgcPotent, highly selective, cell-permeable inhibitor of glucose transporter GLUT1
Features and BenefitsBAY-876 is a chemical probe available through a partnership with the Structural Genomics Consortium (SGC). To learn more and view other SGC chemical probes, visit
sigma.com/SGC.
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Other NotesBAY-588 is used as a negative control and is available from Sigma. To learn more about and purchase BAY-588,
click here.