Merck, SML2357-25MG, Isavuconazole

Name: Isavuconazole
Brand: Merck
SKU: SML2357-25MG

Size:25 mg, (2R, 3R)-3-[4-(4-Cyanophenyl)thiazol-2-yl]-2-(2, 5-difluorophenyl)-1-(1H-1, 2, 4-triazol-1-yl)butan-2-ol, 1-[(2R, 3R)-3-[4-(4-Cyanophenyl)thiazol-2-yl]-2-(2, 5-difluorophenyl)-2-hydroxybutyl]-1, 2, 4-triazole, 4-[2-[(1R, 2R)-2-(2, 5-Difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1, 2, 4-triazol-1-yl)propyl]-4-thiazolyl]benzonitrile, BAL 4815, RO 0094815, ≥98% (HPLC)

Available Catalog Numbers

SML2357-25MG SML2357-5MG

Catalog Number: SML2357-25MG

Pricing

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Category

Phosphatase Inhibitors

Pack Size25 mg

CollectionsMerck Cell Culture Supplements & Reagents: Complete Solutions for Research & Bioproduction Merck Roche Life Science Products for PCR, RT‑PCR & Nucleic Acid Purification

Description

Application
Isavuconazole has been used as an antifungal agent to test its effect on Mucor circinelloides gene transcription. It has also been used
to analyze its in vitro activity against isolates from the R. argillacea species complex A. fumigatus, N. hiratsukae and C. parapsilosis.
Biochem/physiol Actions
Isavuconazole is a triazole antifungal drug. It inhibits fungal sterol biosynthesis by inhibition of cytochrome P450 sterol 14-α-demethylase (CYP51), an enzyme in the sterol biosynthesis pathway that leads from lanosterol to ergosterol. It has been approved for the treatment of both invasive aspergillosis and invasive mucormycosis.
Triazole antifungal drug.

Specifications

General

UNSPSC Code	12352200
NACRES	NA.77
Web Name Suffix Override	≥98% (HPLC), powder, fungal sterol biosynthesis inhibitor
MDL number	MFCD06407745
SMILES string	Fc1c(cc(cc1)F)[C@](O)([C@@H](C)c3[s]cc(n3)c4ccc(cc4)C#N)C[n]2ncnc2
InChI	1S/C22H17F2N5OS/c1-14(21-28-20(10-31-21)16-4-2-15(9-25)3-5-16)22(30,11-29-13-26-12-27-29)18-8-17(23)6-7-19(18)24/h2-8,10,12-14,30H,11H2,1H3/t14-,22+/m0/s1
InChI key	DDFOUSQFMYRUQK-RCDICMHDSA-N
assay	≥98% (HPLC)
form	powder
color	white to beige
solubility	DMSO: 2 mg/mL, clear
storage temp.	2-8°C

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Merck, SML2357-25MG, Isavuconazole

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