Merck, SML2844-25MG, Rivaroxaban

Name: Rivaroxaban
Brand: Merck
SKU: SML2844-25MG

Size:25 mg, (S)-Rivaroxaban, (S)-5-Chloro-N-{[2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]oxazolidin-5-yl]methyl} thiophene-2-carboxamide, 5-Chloro-N-({(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]-1, 3-oxazolidin-5-yl}methyl)thiophene-2-carboxamide, BAY 59-7939, BAY-59-7939, BAY59-7939, 5-Chloro-N-[[(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-5-oxazolidinyl]methyl]-2-thiophenecarboxamide, ≥98% (HPLC)

Available Catalog Numbers

SML2844-25MG SML2844-5MG

Catalog Number: SML2844-25MG

Pricing

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Category

Phosphatase Inhibitors

Pack Size25 mg

CollectionsMerck Cell Culture Supplements & Reagents: Complete Solutions for Research & Bioproduction Merck Roche Life Science Products for PCR, RT‑PCR & Nucleic Acid Purification

Description

Biochem/physiol Actions
Rivaroxaban is an orally active, active site-targeting, highly potent and selective factor Xa (FXa) inhibitor (IC₅₀ = 0.7 nM; no activity against thrombin, trypsin, plasmin, FVIIa, FIXa, FXIa, urokinase, or activated protein C up to 20 μM) with good anticoagulant activity in vitro (dose for doubling fibrin formation time = 230/300 nM in human/rat plasma) and antithrombotic efficacy in vivo (ED₅₀ = 1 mg/kg i.v. or 5 mg/kg p.o. by rat arteriovenous shunt model).

Specifications

General

UNSPSC Code	12352200
NACRES	NA.77
Web Name Suffix Override	≥98% (HPLC), selective factor Xa (FXa) inhibitor, powder
MDL number	MFCD11974010
SMILES string	[s]1c(ccc1C(=O)NC[C@@H]2OC(=O)N(C2)c3ccc(cc3)N4CCOCC4=O)Cl
InChI	1S/C19H18ClN3O5S/c20-16-6-5-15(29-16)18(25)21-9-14-10-23(19(26)28-14)13-3-1-12(2-4-13)22-7-8-27-11-17(22)24/h1-6,14H,7-11H2,(H,21,25)/t14-/m0/s1
InChI key	KGFYHTZWPPHNLQ-AWEZNQCLSA-N
assay	≥98% (HPLC)
form	powder
optical activity	[α]/D -34 to -44, c = 0.3 in DMSO
color	white to beige
solubility	DMSO: 2 mg/mL, clear
storage temp.	2-8°C
Quality Level	100

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Merck, SML2844-25MG, Rivaroxaban

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