Merck, SML2888-5MG, LH1306

Biochem/physiol Actions
LH1306 is a potent programmed cell death-1/programmed death-ligand 1 (PD-1 (CD279, PDCD1)/PD-L1 (B7-H1, PDCD1-L1)) protein-protein interaction (PPI) inhibitor (IC50 = 25 nM by HTRF assay) that induces symmetrically arranged PD-L1 homodimer formation by targeting PD-L1 at the PD-1 binding site. LH1306 effectively blocks cell surface PD-1/PD-L1 interaction between PD-1-expressing Jurkat cells and co-cultured PD-L1-expressing U2OS cells (SHP-1 recruitment IC50 = 334 nM) or co-cultured PD-L1-expressing aAPC/CHO-K1 cells (NFAT signaling restoration EC50 = 4.21 μM).
Potent programmed cell death-1 (PD-1, CD279, PDCD1)/PD-1 ligand (PD-L1, B7-H1, PDCD1-L1) protein-protein interaction (PPI) inhibitor.