Merck, SML2995-25MG, Enviroxime

Name: Enviroxime
Brand: Merck
SKU: SML2995-25MG

Size:25 mg, (E)-(2-Amino-1-(isopropylsulfonyl)-1H-benzo[d]imidazol-6-yl)(phenyl)methanone oxime, (E)-6-[(Hydroxyimino)phenylmethyl]-1-[(1-methylethyl)sulfonyl]-1H-benzimidazol-2-amine, (E)-LY 122771-72, (E)-LY-122771-72, (E)-LY122771-72, (E)-Viroxime, 6-[(E)-(Hydroxyimino)phenylmethyl]-1-[(1-methylethyl)sulfonyl]-1H-benzimidazol-2-amine, EvirX, LY 122772, LY-122772, LY122772, ≥98% (HPLC)

Available Catalog Numbers

SML2995-25MG SML2995-5MG

Catalog Number: SML2995-25MG

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Category

Size Exclusion Resins

Pack Size25 mg

CollectionsMerck Cell Culture Supplements & Reagents: Complete Solutions for Research & Bioproduction Merck Roche Life Science Products for PCR, RT‑PCR & Nucleic Acid Purification

Description

Biochem/physiol Actions
Enviroxime (LY 122772) is a selective phosphatidylinositol 4-kinase type IIIβ (PI4KB, PI4KIIIβ) inhibitor (IC50 = 60 nM/PI4KB vs. 1.917 µM/PI4KA) with antiviral potency against enteroviruses, including rhinovirus (RV plaque reduction IC50 ≤40 ng/mL; HeLa), poliovirus (PV), coxsackievirus (CV). PI4KB is a host factor essential for enterovirus replication, mutations in viral 3A protein that recruits PI4KB to the replication sites result in enviroxime resistance. Enviroxime is also reported to impede PI4K-independent hepatitis C (HCV) replication at least partially by an inhibitory effect on PI3Ks.
Phosphatidylinositol 4-kinase type IIIβ (PI4KB, PI4KIIIβ) inhibitor with antiviral potency against enteroviruses and hepatitis C (HCV) replication.

Specifications

General

UNSPSC Code	41121800
NACRES	NA.21
MDL number	MFCD00866954
SMILES string	NC1=NC(C=CC(/C(C2=CC=CC=C2)=N/O)=C3)=C3N1S(C(C)C)(=O)=O
assay	≥98% (HPLC)
form	powder
color	, White to very dark grey
solubility	DMSO: 2 mg/mL, clear
storage temp.	2-8°C
Quality Level	100

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Merck, SML2995-25MG, Enviroxime

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