Merck, SML3015-10MG, Arimoclomol maleate

Name: Arimoclomol maleate
Brand: Merck
SKU: SML3015-10MG

Size:10 mg, (R)-3-(Chloro(2-hydroxy-3-(piperidin-1-yl)propoxyimino)methyl)pyridine 1-oxide, maleate salt, (+)-(R)-N-[2-Hydroxy-3-(1-piperidinyl)propoxy]pyridine-1-oxide-3-carboximidoyl chloride, maleate salt, Anti-neurodegeneration agent 1, BRX 220, BRX-220, BRX220, N-[(2R)-2-Hydroxy-3-(1-piperidinyl)propoxy]-3-pyridinecarboximidoyl chloride 1-oxide, maleate salt, maleate salt, ≥98% (HPLC)

Available Catalog Numbers

SML3015-10MG SML3015-50MG

Catalog Number: SML3015-10MG

Pricing

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Category

Size Exclusion Resins

Pack Size10 mg

CollectionsMerck Cell Culture Supplements & Reagents: Complete Solutions for Research & Bioproduction Merck Roche Life Science Products for PCR, RT‑PCR & Nucleic Acid Purification

Description

Biochem/physiol Actions
Arimoclomol is an orally available, CNS-penetrant coinducer of heat shock proteins (HSPs), notably HSP70, that exhibits in vivo efficay in disease models of diabetes, Gaucher disease (GD), sporadic inclusion body myositis (sIBM), and neurological disorders, including amyotrophic lateral sclerosis (ALS) and Niemann-Pick disease type C1 (NPC1). Note: arimoclomol maleate and citrate salt forms are known as BRX-220 and BRX-345, respectively.
Orally available, CNS-penetrant coinducer of heat shock proteins (HSPs), notably HSP70 (HSP72), with in vivo ALS, GD, NPC1, and sIBM therapeutic efficacy.

Specifications

General

UNSPSC Code	12352200
NACRES	NA.77
MDL number	MFCD28143527
InChI	1S/C14H20ClN3O3.C4H4O4/c15-14(12-5-4-8-18(20)9-12)16-21-11-13(19)10-17-6-2-1-3-7-17;5-3(6)1-2-4(7)8/h4-5,8-9,13,19H,1-3,6-7,10-11H2;1-2H,(H,5,6)(H,7,8)/b;2-1-/t13-;/m1./s1
SMILES string	Cl/C(C1=CC=C[N+]([O-])=C1)=N\OC[C@@H](CN2CCCCC2)O.O=C(O)/C=C\C(O)=O
InChI key	OHUSJUJCPWMZKR-FEGZNKODSA-N
assay	≥98% (HPLC)
form	powder
color	white to beige
solubility	H2O: 2 mg/mL, clear
storage temp.	2-8°C
Quality Level	100

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Merck, SML3015-10MG, Arimoclomol maleate

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