Merck, SRE0011-5G, γ-Globulins from bovine blood

General description
Bovine gamma globulin (BGG) is an important component of the immune system of cows and other bovines. BGG is found in the blood of bovines and is primarily used in the production of medical products such as vaccines, serums, and diagnostic reagents. BGG can also be used to treat certain medical conditions, such as hepatitis B, as well as to boost immunity in humans and other animals.
Plasma protein fraction rich in antibodies
γ-Globulins are immunoglobulins that contain IgM, IgA, and IgY. They are glycoproteins produced by plasma cells. The immunoglobulins are heterodimeric molecules comprising two light chains and two heavy chains linked together by disulfide bonds.
Application
γ-Globulins from bovine blood has been used along with polyethylene glycol (PEG) to investigate the kinetics of liquid-liquid phase separation (LLPS) in its temporary and arrested state. It has also been used as a parent solution to prevent bacterial growth and study the antibody system with LLPS and highly elevated protein concentrations in arrested transition.
Bovine γ-globulin has been used as an immunological challenge in studies of mechanisms of immunotolerance.
Biochem/physiol Actions
Immunoglobulins are implicated in the activation of the complement system and the opsonization of microbes for phagocytosis. It is also involved in the neutralization of toxins and viruses and blocks the attachment of microbes to mucosal surfaces. They protect our bodies against fungi, viruses, and bacteria. Immunodeficiency is associated with recurrent infectious diseases.
Preparation Note
Prepared from Cohn Fraction II, III