Description
General description
Butyrylcholinesterase (BChE) belongs to the same structural class of proteins, the esterase/lipase family, as acetylcholinesterase (AchE, EC 3.1.1.7). They are serine hydrolases that share substantial structural similarities, but differ in substrate specificities and inhibitor sensitivities. BChE can, unlike AChE, efficiently hydrolyze larger esters of choline such as butyrylcholine and benzoylcholine. Although BChE is found in the serum, hemopoietic cells, liver, lung, heart, and the central nervous system of vertebrates, it has no known physiological function.
Application
Selective inhibition of BChE activity can be used in the detection of organophosphates.
Its use in the treatment of organophosphate toxicity shows promise and there is a correlation between the level of BChE in human blood and degree of protection against potentially toxic nerve agents.
There has also been interest in the roles of cholinesterases with regard to Alzheimer’s disease. Investigations into selective inhibitors may provide a clearer picture of the physiological role of BChE in both healthy and diseased individuals.
Features and Benefits
Features: Qualified Raw Materials: Products that meet the stringent requirements of the Elevated Assurance Program, ensuring compliance with regulatory standards.
Comprehensive Documentation: Includes essential documents such as certificates, impurity profiles, and declarations to support audits and risk assessments.
M-Clarity™ Quality Attributes: Products are classified within the MQ300 quality segment or higher, demonstrating superior quality assurance. M-Clarity™ Program
Confirmed Process Controls: Established processes that ensure consistency and reliability in manufacturing.
Enhanced Change Notification: Timely updates on any changes to product specifications or processes, ensuring transparency and compliance.
Freely Available Dossiers: Access to robust, ready-to-present product dossiers that include: Site quality assessment
ISO 9001 certificate
Detailed product specifications
Relevant declarations/statements (e.g., animal origin content, BSE/TSE, nitrosamine)
Benefits: Regulatory Compliance: Helps you meet compliance standards effectively, reducing the risk of regulatory issues.
Audit Readiness: Instills confidence during audits with comprehensive documentation and confirmed process controls, demonstrating your commitment to high-quality products.
Operational Transparency: Supports supply chain transparency, allowing you to track and verify the quality of raw materials.
Enhanced Support: Provides exceptional quality-related information and tailored assistance to meet your specific needs.
Risk Mitigation: Facilitates thorough risk assessments with detailed documentation, helping you manage potential compliance challenges.
Informed Decision-Making: Access to clear and comprehensive product information enables better decision-making and enhances operational efficiency.
Other Notes
One unit will hydrolyze 1.0 micromole of butyrylcholine to choline and butyrate per minute at pH 8.0 at 37 deg C.
Legal Information
M-CLARITY is a trademark of Merck KGaA, Darmstadt, Germany
