Merck, SRP3317-50UG, ANGPTL-3 human

Name: ANGPTL-3 human
Brand: Merck
SKU: SRP3317-50UG

Size:50 μg, ANG-5, ANGPT5, recombinant, expressed in CHO cells, ≥98% (SDS-PAGE), ≥98% (HPLC)

Catalog Number: SRP3317-50UG

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Category

Cell-Free Protein Expression Kits

Pack Size50 µg

CollectionsMerck Cell Culture Supplements & Reagents: Complete Solutions for Research & Bioproduction Merck Roche Life Science Products for PCR, RT‑PCR & Nucleic Acid Purification

Description

General description
ANGPTL-3 (Angiopoietin like protein 3) is a member of the angiopoietin family of structurally related proteins, characterized by a coiled N-terminal domain and a C-terminal fibrinogen like domain. It is mainly present in the hepatocytes and is also secreted into circulation. The gene is mapped to human chromosome 1p31.
Recombinant human ANGPTL-3 is a glycoprotein that migrates by SDS-PAGE (sodium dodecyl sulfate polyacrylamide gel electrophoresis) analysis at an apparent molecular weight of 62kDa, and contains 452 amino acid residues including a C-terminal His tag.
Biochem/physiol Actions
ANGPTL-3 (Angiopoietin like protein 3) can exert activities related to both angiogenesis and lipid metabolism. ANGPTL-3 inhibits lipoprotein lipase (LPL) and endothelial lipase (EL), which has the effect of increasing plasma levels of triglycerides and HDL (high-density lipoprotein)-associated cholesterol. The fibrinogen like portion of the ANGPTL-3 protein can bind α-5/β-3 integrins leading to endothelial cell adhesion and migration. Mutations in this gene can result in familial combined hypobetalipoproteinemia.
Physical form
Lyophilized from 10mM Sodium Phosphate, pH 7.5.
Preparation Note
Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.

Specifications

General

NACRES	NA.32
UNSPSC Code	12352202
biological source	human
recombinant	expressed in CHO cells
assay	≥98% (HPLC)
form	lyophilized
mol wt	62.0 kDa
packaging	pkg of 50 μg
impurities	endotoxin, tested
color	white to off-white
UniProt accession no.	Q9Y5C1
shipped in	wet ice
storage temp.	−20°C
Gene Information	human ... ANGPTL3(27329)

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Merck, SRP3317-50UG, ANGPTL-3 human

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