Merck, V9879-1MG, [Arg8]-Vasopressin acetate salt

General description
Arginine vasopressin is a nonapeptide. It is produced by anterior hypothalamus nerve cells.
Application
[Arg8]-Vasopressin acetate salt has been:
used as a vasopressin receptor agonist to test vasopressin receptors
used to evoke peripheral V1a receptor-mediated vasoconstriction
as a supplement in Ham′s F12/Dulbecco′s modified Eagle′s medium for proximal tubule and glomerular explant cell culture

Biochem/physiol Actions
Endogenous antidiuretic hormone in most mammalian species. It is released into the blood from nerve terminals in the posterior pituitary and median eminence. Arg8-vasopressin is also a neurotransmitter in the central nervous system. It is implicated in a variety of physiological processes including diuresis, vasoregulation, and memory. Regulates water balance by antidiuretic action; contracts arterioles (vasopressor action).
Endogenous antidiuretic hormone in most mammalian species; neurotransmitter in the central nervous system implicated in a variety of physiological processes including diuresis, vasoregulation, and memory.
Preparation Note
[Arg8]-Vasopressin acetate salt dissolves water at 20 mg/ml to yield a clear colorless to faint yellow solution.
Other Notes
Lyophilized from 0.5% acetic acid