| Cell Permeability | Yes |
|---|---|
| Form | Powder |
| Labeling Method | Chemical Labeling |
| Molecular Weight (g/mol) | 334.32 |
| PEGylated | No |
| Product Line | Pierce |
| Quantity | 50 mg |
| Reactive Moiety | Maleimide, NHS Ester |
| Shipping Condition | Ambient |
| Solubility | DMF, DMSO |
| Spacer Arm Length | 8.3 Å |
| Water Soluble | No |
| Chemical Reactivity | Amine-Sulfhydryl |
| Cleavable | By Thiols |
| Crosslinker Type | Heterobifunctional |
| Format | Standard, Single-use |
| Product Type | Crosslinker |
| Spacer | Short (<10 Å) |
| Unit Size | Each |
Answer:This configuration contains 50 mg of SMCC.
Answer:The NHS ester reacts with primary amines and the maleimide reacts with sulfhydryls.
Answer:SMCC has a molecular weight of 334.32 g/mol.
Pierce™ SMCC is a heterobifunctional crosslinker for covalent coupling of amine-containing molecules to sulfhydryl-containing molecules. This configuration contains 50 mg of powder with a molecular weight of 334.32 g/mol. The NHS ester reacts with primary amines, while the maleimide group reacts selectively with sulfhydryls. SMCC has a short spacer arm of approximately 8.3 Å and is soluble in organic solvents such as DMF and DMSO. The reagent is widely used to prepare antibody conjugates, maleimide-activated carrier proteins, protein-protein conjugates, and other bioconjugates. It is cell permeable and is intended for research workflows requiring controlled amine-to-thiol crosslinking chemistry.
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