Thermo Fisher, 22424, TMS(PEG)12 Branched Methyl-PEG-NHS-Ester Reagent

Quantity: 1 g
Unit Size: Each
TMS(PEG)12 is the abbreviation for a branched trimethyl (TM) and succinimide ester (S) derivative of polyethylene glycol (PEG) for efficient and specific modification of primary amines. Each methyl-terminated PEG (mPEG) branch contains 12 ethylene glycol units. The three branches are attached to a 4-unit PEG stem that contains an amine-reactive N-hydroxysuccinimide (NHS) ester at the distal end. The NHS ester is spontaneously reactive with primary amines (—NH_2), providing for efficient PEGylation of proteins, peptides and other amine-containing molecules or surfaces.Highlights:
• NHS-activated for efficient PEGylation of primary amines at pH 7-9; reaction of NHS-ester group results in formation of stable, irreversible amide bonds
• Pure compound with defined structure and molecular weight, ensuring reproducible protein-modification effects
• PEG spacer provides unique advantages, including increased stability, reduced tendency toward aggregation and reduced immunogenicity
• Easy-to-follow instructions increase the likelihood of a successful outcome