Thermo Fisher, 27-1607-12, 2'-Fluoro-iBu-G Phosphoramidite, standard grade, 28-400 finish bottle

Quantity: 0.5 g
Unit Size: Each
2'-Fluoro-iBu-G CEP is a phosphoramidite containing 5' DMT and the nucleoside guanosine (G) with 2'-Fluoro protection, for use in oligonucleotide synthesis. Located in the ideal oligo position, the highly electronegative fluorine (2'-Fluoro) modification adopts a more thermodynamically stable A-form helix on hybridization to its target. Showing improved affinity and some nuclease resistance (compared to 2'-OH), the 2'-F modification has been proven useful in antisense, siRNA, and aptamer applications. The 'standard grade' marking denotes a baseline level of purity verified with analytical methods, and proven to be suitable for most oligo synthesis requirements. This product is supplied in a 30-mL amber bottle with a 28-400 finish neck style, which is compatible with most MerMade synthesizers. Features:• Full chemical name: 5'-O-(4,4'-Dimethoxytrityl)-N^2-isobutyryl-2'-fluoroguanosine-3'-O-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite• Molecular formula: C_44H_53FN_7O_8P• Base: G• Base Protection: iBu• Formula weight: 857.4 g/mol• CAS number: 144089-97-4• HPLC purity: >98%• ^31P NMR purity: ≥98%