Thermo Fisher, 28103-104630, Hypersil™ BDS C18 Columns

Hypersil™ BDS C18 Column 28103-104630 is used for reversed-phase HPLC methods that need a base-deactivated silica surface and dependable C18 selectivity. This configuration is 100 mm × 4.6 mm and contains 3 µm spherical, fully porous base-deactivated silica particles. The endcapped C18 phase has a 130 Å pore size, 170 m²/g surface area and 11% carbon load, with USP L1 classification. The column supports pressures up to 5800 psi (400 bar), operates over pH 2–8 and can be used at temperatures up to 60 °C. Base-deactivated silica reduces unwanted interactions associated with active silanol sites, which is useful in methods involving basic or ionizable small molecules. The 3 µm particles provide higher efficiency than classical 5 µm formats while retaining a conventional 4.6 mm internal diameter. This makes the column suitable for routine analytical HPLC, method optimization and transfer of BDS C18 methods that require stable, familiar reversed-phase behavior.