Thermo Fisher, A15393.03, 6,7-Dihydroxycoumarin, 98+%

Name: 6,7-Dihydroxycoumarin, 98+%
Brand: Thermo Fisher
SKU: A15393.03

Quantity: 1 g, Unit Size: Each, In the presence of esculetin and HA14-1 (sc-205911) expression of the death receptor 4 (DR4) has been observed to be upregulated and extracellular-regulated kinase (ERK) to be activated. Other studies suggest that esculetin upregulates death receptor 5 (DR5) protein expression, and enhances TRAIL-induced apoptosis. It also inhibits the activity of 12-LO (12-lipoxygenase), and decreases leukotriene biosynthesis during 5-LO inhibition. This Thermo Scientific Chemica

Catalog Number: A15393.03

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Category

Insect Cell Expression Systems

TagsChemicals Organic compounds Phenylpropanoids and polyketides Coumarins and derivatives

CollectionsThermo Fisher Chemicals Collection — Analytical Solvents, Reagents & CoAs Thermo Fisher Clinical Analyzers & Instruments for Diagnostic Labs Thermo Fisher General Lab Supplies for Daily Workflows — Nalgene, Nunc, Samco & Matrix

Description

Quantity: 1 g
Unit Size: Each
ApplicationsIn the presence of esculetin and HA14-1 (sc-205911) expression of the death receptor 4 (DR4) has been observed to be upregulated and extracellular-regulated kinase (ERK) to be activated. Other studies suggest that esculetin upregulates death receptor 5 (DR5) protein expression, and enhances TRAIL-induced apoptosis. It also inhibits the activity of 12-LO (12-lipoxygenase), and decreases leukotriene biosynthesis during 5-LO inhibition.SolubilitySoluble in DMSO, DMF, diluted alkalies with blue fluorescence, and acetone. Slightly soluble in water. Insoluble in ether. Moderately soluble in Glacial acetic acid, and hot ethanol.NotesStore in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from oxidizing agents.

Specifications

General

Beilstein	152788
CAS	305-01-1
ChEBI	CHEBI:490095
Chemical Name or Material	6,7-Dihydroxycoumarin
EINECS Number	206-161-5
Formula Weight	178.15
Health Hazard 1	H315-H319-H335
Health Hazard 2	<b>GHS H Statement</b><br />H315-H319-H335<br />Causes skin irritation.<br />Causes serious eye irritation.<br />May cause respiratory irritation.
Health Hazard 3	P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P362-P501c
IUPAC Name	6,7-dihydroxychromen-2-one
InChI Key	ILEDWLMCKZNDJK-UHFFFAOYSA-N
MDL Number	MFCD00006874
Melting Point	∼270°C (decomposition)
Merck Index	14,3697
Molecular Formula	C9H6O4
PubChem CID	5281416
RTECS Number	GN6382500
Recommended Storage	Keep cold
SMILES	C1=CC(=O)OC2=CC(=C(C=C21)O)O
Solubility Information	Soluble in DMSO,DMF,diluted alkalies with blue fluorescence,and acetone. Slightly soluble in water. Insoluble in ether. Moderately soluble in Glacial acetic acid,and hot ethanol.

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Thermo Fisher, A15393.03, 6,7-Dihydroxycoumarin, 98+%

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