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Epigenetic regulation of gene expression is proving to be key in the development and progression of a host of human diseases. The Silencer™ Select Human Epigenetics siRNA Library contains 1563 Ambion™ Silencer Select highly potent, chemically-modified siRNAs targeting 521 epigenetic enzymes, including those mediating epigenetic signaling through the acetylation and methylation of histones. This library was designed using the most up-to-date genome databases, including the NCBI RefSeq database and cross-referenced to the Gene Ontology Consortium (GO) database and/or the HUGO Gene Nomenclature Committee (HGNC). The Silencer Select siRNAs are designed using Thermo Fisher Scientific's leading design algorithms—along with our novel locked nucleic acid (LNA) modifications, this helps to ensure the efficacy, specificity and potency required for accurate and consistent phenotype data for RNAi screening against epigenetic gene knockdown studies.
• Superior efficacy—Reduce off target effects by up to 90% due to latest design algorithms and LNA chemical modifications
• Highest efficiency—Perform knockdown studies with 100-fold more potent siRNAs than currently available siRNAs
• Dependable—Achieve faster discoveries via consistency of gene knockdown and reliability of phenotypic results
• Convenient—Reduce data de-convolution and accelerate target validation with our arrayed format
• Customizable—Choose the best option for your workflow demands, including additional siRNA scales and pooled formatsWhy use the Silencer Select Human Epigenetics siRNA Library?Together with careful bioinformatics selection of gene targets, Silencer Select siRNAs are optimized using our most up-to-date design algorithms, proprietary chemical modifications and high quality synthesis to help ensure desired RNAi outcomes. The Silencer Select Human Epigenetics siRNA Library contains our pre-designed and when available, validated siRNAs generated with highest potency and specificity in mind so you can focus on the highest data quality instead of performance issues. Thermo Fisher Scientific's Ambion Silencer Select siRNAs are also backed by the best in industry guarantee.Silencer Select siRNA libraries empower you with highly potent siRNAs to maximize discovery with even lessAmbion Silencer Select siRNAs are designed with the highest potency of available siRNAs, resulting in 100-fold more potent siRNAs and allowing gene knockdowns at the lowest concentrations (see figure below). The highly potent Silencer Select siRNAs allow you to use even lower concentrations of siRNAs, which helps to minimize off target effects, reduce false negative data and maximize siRNA library output for additional screens and data validation. The Silencer Select Human Epigenetics siRNA Library contains 0.25 nmol of each highly potent siRNA, sufficient for at least 500 transfections (at 5 nM siRNA, 100 μL transfection volume).Flexibility to meet your workflow needsThermo Fisher Scientific offers a comprehensive list of pre-defined or custom siRNA libraries against human, mouse or rat genes with 1, 2, or 5 nmol of each siRNA or larger sizes. For a complete gene list, additional information or to discuss your research with one of our technical experts, contact your local sales representative or e-mail us at
[email protected].
