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Mutations that cause a loss or reduction in gene function can result in the progression to cancer, usually in combination with other genetic changes. Tumor suppressor genes, or anti-oncogenes, can protect cells on the path to becoming cancerous. The Silencer™ Select Human Tumor Suppressor siRNA Library contains 2,235 Ambion™ Silencer Select siRNAs targeting 745 tumor suppressor genes. This library of highly potent, chemically-modified siRNAs was designed using the most up-to-date genome databases, including the NCBI RefSeq database and cross-referenced to the Gene Ontology Consortium (GO) database and/or the HUGO Gene Nomenclature Committee (HGNC) as well as the Tumor Suppressor Gene Database (TSGene). Silencer Select siRNAs are designed with Thermo Fisher Scientific's leading design algorithms and locked nucleic acid (LNA) modifications to help ensure efficacy, specificity and potency and provide accurate and consistent phenotype data for RNAi screening against tumor suppressor genes.
• Superior efficacy—Reduce off target effects by up to 90% due to latest design algorithms and LNA chemical modifications
• Highest efficiency—Perform knockdown studies with 100-fold more potent siRNAs than currently available siRNAs
• Dependable—Achieve faster discoveries via consistency of gene knockdown and reliability of phenotypic results
• Convenient—Reduce data de-convolution and accelerate target validation with our arrayed format
• Customizable—Choose the best option for your workflow demands, including additional siRNA scales and pooled formatsWhy use the Silencer Select Human Tumor Suppressor siRNA Library?Together with careful bioinformatics selection of gene targets, Silencer Select siRNAs are optimized with latest design algorithms, proprietary chemical modifications and high quality synthesis to help ensure desired RNAi outcomes. The Silencer Select Human Tumor Suppressor siRNA Library contains our pre-designed and when available, validated siRNAs generated with highest potency and specificity in mind so you can focus on the highest data quality backed by the best in industry guarantee.Silencer Select siRNA libraries empower you with highly potent siRNAs to maximize discovery with even lessAmbion Silencer Select siRNAs are designed with the highest potency of available siRNAs resulting in 100-fold more potent siRNAs and allowing gene knockdowns at the lowest concentrations (see figure below). The highly potent Silencer Select siRNAs allows you to use even lower concentrations of siRNAs, which helps to minimize off target effects, reduce false negative data and maximize siRNA library output for additional screens and data validation. The Silencer Select Human Tumor Suppressor siRNA Library contains 0.25 nmol of each highly potent siRNA, sufficient for at least 500 transfections (at 5 nM siRNA, 100 μL transfection volume).Flexibility to meet your workflow needsThermo Fisher Scientific offers a comprehensive list of pre-defined or custom siRNA libraries to human, mouse or rat genes with 1, 2, or 5 nmol of each siRNA or larger sizes. For a complete gene list, additional information or to discuss your research with one of our technical experts, contact your local sales representative or e-mail us at
[email protected].
