Thermo Fisher, GM3001, BSEP Vesicular Transport Assay Reagent Set

Quantity: 100 Assays
Unit Size: Each
The BSEP Vesicular Transport Assay Reagent Set is a ready-to-use kit containing all reagents needed for vesicular transport assay except for the vesicles themselves. The reagent set can be used for vesicular transport assay using radioisotope-labeled or non-labeled compound. This kit has enough material to perform 100 vesicular transport assays.Use The BSEP Vesicular Transport Assay Reagent Set to:
• Investigate the transporter interactions of your drug candidates
• Assess potential for transporter-mediated drug-drug interactions
• Obtain high quality results with a large signal to noise ratiosConcept Behind ABC Transporter VesiclesABC transporter vesicles are easy-to-use, efficient reagents for early assessment of a drug candidate’s substrate and drug interaction potential. While ABC transporters typically mediate the export of substrates out of cells, transporters expressed on these inside-out vesicles import substrates into the vesicles. It is therefore possible to quantitatively evaluate transport activity for your compound by determining the amount incorporated into the vesicles.Clear and Reliable ResultsPrepared from Sf9 cells which have been engineered to over-express specific ABC transporters, these 'inside-out' vesicles provide high levels of transporter activity with low background, giving you a clear signal if your compound is a substrate or inhibitor of a specific efflux transporter.Kit CompatibilityOur BSEP Vesicular Transport Assay Reagent Set is designed for use with BSEP Vesicles. The 100 vesicular transport assays that can be performed with this kit will require two BSEP Vesicle productsFor Research Use Only. Not intended for animal or human therapeutic or diagnostic use.