Thermo Fisher, J60308.MA, Tyrphostin A23, 99%, Thermo Scientific Chemicals

Quantity: 10 mg
Unit Size: Each
ApplicationsTyrphostin inhibit protein tyrosine kinase and block the EGF-dependent autophosphorylation of the receptor. The inhibitors can bind to the EGF receptor kinase domain with different affinities. It also inhibits PDGFR kinase. Tyrphostin A23 has been used to inhibit agonist-induced GP IIb- IIIa activation in permeabilized platelets and in other studies to block calcium channel currents in vascular smooth muscle cells. . Tyrphostin A23 can also inhibit the internalization of (125)I-transferrin in Heb7a cells.SolubilitySoluble in DMSO, ethanol, or DMFNotesStore in cool, dry place in a tightly sealed container. Store away from oxidizing agents, acids, heat.