Thermo Fisher, J60727.MA, Bleomycin sulfate

Quantity: 10 mg
Unit Size: Each
General Description
• Bleomycin sulfate was initially isolated from Streptomyces verticillus. It is a glycopeptide compound with antibiotic activity
• It has the ability to induce oxidative cleavage of the DNA backbone, leading to apoptosis
• Bleomycin sulfate can form a complex with iron that reduces oxygen to superoxide and hydroxyl radicals. These reactive oxygen species can cause single- and double-stranded breaks in DNA as well as promote carbohydrate oxidation, lipid peroxidation, and alterations in prostaglandin synthesis and degradationApplication
• It can be used to inhibit DNA metabolism and slow or stop cell growth. This property explains its anticancer activity
• Bleomycin sulfate can also be used to degrade RNA as it is more selective to RNA than DNA
• Local injections of bleomycin sulfate in mouse models can induce sclerotic skin mimicking scleroderma
• In laboratory research, bleomycin is used to induce pulmonary fibrosis in mice