Thermo Fisher, J60727.MCR, Bleomycin sulfate

Name: Bleomycin sulfate
Brand: Thermo Fisher
SKU: J60727.MCR

Quantity: 1 mg, Unit Size: Each, Bleomycin sulfate is used as a glycopeptide antibiotic. It is capable of inducing oxidative cleavage of the DNA backbone, leading to apoptosis and also degrades RNA, and has been reported to display selectivity for RNA over DNA. Bleomycin acts as a sclerosing agent. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar

Catalog Number: J60727.MCR

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Category

Hormones for Cell Culture

Pack Size1 mg

TagsCell Culture Media Antibiotics Supplements and Reagents Cell Culture Reagents Antibiotics and Supplements

CollectionsThermo Fisher Cell Culture Media & Supplements | Serum-Free, Chemically Defined Thermo Fisher Clinical Analyzers & Instruments for Diagnostic Labs Thermo Fisher General Lab Supplies for Daily Workflows — Nalgene, Nunc, Samco & Matrix

Description

Quantity: 1 mg
Unit Size: Each
General Description
• Bleomycin sulfate was initially isolated from Streptomyces verticillus. It is a glycopeptide compound with antibiotic activity
• It has the ability to induce oxidative cleavage of the DNA backbone, leading to apoptosis
• Bleomycin sulfate can form a complex with iron that reduces oxygen to superoxide and hydroxyl radicals. These reactive oxygen species can cause single- and double-stranded breaks in DNA as well as promote carbohydrate oxidation, lipid peroxidation, and alterations in prostaglandin synthesis and degradationApplication
• It can be used to inhibit DNA metabolism and slow or stop cell growth. This property explains its anticancer activity
• Bleomycin sulfate can also be used to degrade RNA as it is more selective to RNA than DNA
• Local injections of bleomycin sulfate in mouse models can induce sclerotic skin mimicking scleroderma
• In laboratory research, bleomycin is used to induce pulmonary fibrosis in mice

Specifications

General

CAS	9041-93-4
Chemical Name or Material	Bleomycin sulfate
EINECS Number	232-925-2
Health Hazard 1	H340-H351-H361d
Health Hazard 2	<b>GHS H Statement</b><br />H340-H351<br /> May cause genetic defects. <br />Suspected of causing cancer.
Health Hazard 3	P201-P202-P281-P308+P313-P501c
IUPAC Name	[2-[2-[2-[[6-amino-2-[3-amino-1-[(2,3-diamino-3-oxopropyl)amino]-3-oxopropyl]-5-methylpyrimidine-4-carbonyl]amino]-3-[[5-[[1-[2-[4-[4-(3-dimethylsulfoniopropylcarbamoyl)-1,3-thiazol-2-yl]-1,3-thiazol-2-yl]ethylamino]-3-hydroxy-1-oxobutan-2-yl]amino]-3-hyd
InChI Key	WUIABRMSWOKTOF-UHFFFAOYSA-N
MDL Number	MFCD00070310
Merck Index	14,1318
Molecular Formula	C55H85N17O25S4
PubChem CID	131664136
RTECS Number	EC5991990
Recommended Storage	Keep cold
SMILES	CC1=C(N=C(N=C1N)C(CC(=O)N)NCC(C(=O)N)N)C(=O)NC(C(C2=CN=CN2)OC3C(C(C(C(O3)CO)O)O)OC4C(C(C(C(O4)CO)O)OC(=N)[O-])O)C(=O)NC(C)C(C(C)C(=O)NC(C(C)O)C(=O)NCCC5=NC(=CS5)C6=NC(=CS6)C(=O)NCCC[S+](C)C)O.OS(=O)(=O)O
Solubility Information	Soluble in water or DMSO

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Thermo Fisher, J60727.MCR, Bleomycin sulfate

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