Thermo Fisher, J61383.MC, (+/-)-Equol, Thermo Scientific Chemicals

Name: (+/-)-Equol, Thermo Scientific Chemicals
Brand: Thermo Fisher
SKU: J61383.MC

Quantity: 100 mg, Unit Size: Each, (±)-Equol exhibits EC50 values of 200 and 74 nM for human ERα and ERβ, respectively and induces breast cancer cell proliferation in vitro at concentrations as low as 100 nM. It is a weak estrogenic agonist, and competitive inhibitor of 17β-estradiol at the estradiol receptor. It inhibits 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced neoplastic cell transformation by targeting the MEK/ERK/p90RSK/activator protein-1 signalling pathway. It functions as a DHT

Catalog Number: J61383.MC

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Category

Protein Concentration Devices

Pack Size100 mg

TagsChemicals Organic compounds Phenylpropanoids and polyketides Isoflavonoids

CollectionsThermo Fisher Chemicals Collection — Analytical Solvents, Reagents & CoAs Thermo Fisher Clinical Analyzers & Instruments for Diagnostic Labs Thermo Fisher General Lab Supplies for Daily Workflows — Nalgene, Nunc, Samco & Matrix

Description

Quantity: 100 mg
Unit Size: Each
Applications(+/-)-Equol exhibits EC50 values of 200 and 74 nM for human ERα and ERβ, respectively and induces breast cancer cell proliferation in vitro at concentrations as low as 100 nM. It is a weak estrogenic agonist, and competitive inhibitor of 17β-estradiol at the estradiol receptor. It inhibits 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced neoplastic cell transformation by targeting the MEK/ERK/p90RSK/activator protein-1 signalling pathway. It functions as a DHT blocker.SolubilitySoluble in DMSO and methanol or 100% ethanol. Insoluble in water.NotesHygroscopic. Incompatible with oxidizing agents and heat.

Specifications

General

Beilstein	87752
CAS	94105-90-5
Chemical Name or Material	(+/-)-Equol
Color	White
Formula Weight	242.27
IUPAC Name	3-(4-hydroxyphenyl)-3,4-dihydro-2H-chromen-7-ol
InChI Key	ADFCQWZHKCXPAJ-UHFFFAOYNA-N
MDL Number	MFCD00016662
Melting Point	172°C to 176°C
Merck Index	14,3644
Molecular Formula	C15H14O3
PubChem CID	382975
Recommended Storage	Store at -20°C
SMILES	OC1=CC=C(C=C1)C1COC2=C(C1)C=CC(O)=C2
Sensitivity	Hygroscopic
Solubility Information	Soluble in DMSO and methanol or 100% ethanol. Insoluble in water.
Synonym	3-4-hydroxyphenyl chroman-7-ol
TSCA	No
Molecular Weight (g/mol)	242.27
Physical Form	Crystalline Powder
Quantity	100 mg
Unit Size	Each

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Thermo Fisher, J61383.MC, (+/-)-Equol, Thermo Scientific Chemicals

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