Thermo Fisher, J62452.06, Melatonin, 99+%

Name: Melatonin, 99+%
Brand: Thermo Fisher
SKU: J62452.06

Quantity: 5 g, Unit Size: Each, Melatonin acts as a neurohormone that upregulates antioxidant enzymes and inhibits rat NOS1. It also acts as a particularly significant endogenous antioxidant. Melatonin is a rat NOS1 (nNOS) inhibitor. Melatonin is an activator of MEL-1A-R and MEL-1B-R. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item

Catalog Number: J62452.06

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Category

Modifying Enzymes

TagsChemicals Organic compounds Organoheterocyclic compounds Indoles and derivatives

CollectionsThermo Fisher Chemicals Collection — Analytical Solvents, Reagents & CoAs Thermo Fisher Clinical Analyzers & Instruments for Diagnostic Labs Thermo Fisher General Lab Supplies for Daily Workflows — Nalgene, Nunc, Samco & Matrix

Description

Quantity: 5 g
Unit Size: Each
General Description • Melatonine is a hormone produced by the pineal gland that shows several biological activities, including the somnolence, sleep-wake cycle, circadian rhythm, stress response, aging, and immunity activities• It shows antioxidant, autocoid, paracoid, hormonal, anti- inflammatory and anti-apoptotic activitiesApplications• Melatonin shows neurohormonal activity and can upregulate antioxidant enzymes and inhibit rat NOS1• Melatonin has been reported to be an activator of MEL-1A-R and MEL-1B-R• The production and secretion of melatonine are dependent on beta-adrenergic receptor function• During melatonine synthesis, the essential amino acid L-tryptophan is used as a precursor• This compound inhibits apoptosis in immune cells and neurons, and enhances apoptotic cell death of cancer cells• It can inhibit proliferation and metastasis of breast cancer cells by modulating Rho-associated kinase protein-1 expression

Specifications

General

RTECS Number
Beilstein	205542
CAS	73-31-4
ChEBI	CHEBI:16796
Chemical Name or Material	Melatonin
Color	White
EINECS Number	200-797-7
Formula Weight	232.28
Health Hazard 1	<b>Warning</b>
Health Hazard 2	<b>GHS H Statement</b><br />H361<br /> Suspected of damaging fertility or the unborn child.
Health Hazard 3	<b>GHS P Statement</b><br />P281-P201-P202-P308+P313-P405-P501a<br />Use personal protective equipment as required.<br />Obtain special instructions before use.<br />Do not handle until all safety precautions have been read and understood.<br />IF exposed or concerned: Get medical advice/attention.<br />Store locked up.<br />Dispose of contents/container in accordance with local/regional/national/international regulations.
IUPAC Name	N-[2-(5-methoxy-1H-indol-3-yl)ethyl]acetamide
InChI Key	DRLFMBDRBRZALE-UHFFFAOYSA-N
MDL Number	MFCD00005655
Melting Point	116°C to 120°C
Merck Index	14,5816
Molecular Formula	C13H16N2O2
PubChem CID	896

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Thermo Fisher, J62452.06, Melatonin, 99+%

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