Thermo Fisher, J63191.03, Cyclosporin A, 99+%

Name: Cyclosporin A, 99+%
Brand: Thermo Fisher
SKU: J63191.03

Quantity: 1 g, Unit Size: Each, Ciclosporin A induces apoptosis and inhibits angiogenesis induced by VEGF. It also suppresses the replication of hepatitis C virus genome in cultured hepatocytes. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientif

Catalog Number: J63191.03

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Protein-Free Media

TagsCell Culture Media Antibiotics Supplements and Reagents Cell Culture Reagents Antibiotics and Supplements

CollectionsThermo Fisher Cell Culture Media & Supplements | Serum-Free, Chemically Defined Thermo Fisher Clinical Analyzers & Instruments for Diagnostic Labs Thermo Fisher General Lab Supplies for Daily Workflows — Nalgene, Nunc, Samco & Matrix

Description

Quantity: 1 g
Unit Size: Each
General Description
• Cyclosporin A is a non-polar cyclic oligopeptide produced by the fungus Tolypocladium inflatumApplications
• It inhibits phosphoprotein phosphatase
• Cyclosporin A binds to the cellular protein cytophilin and inhibits the enzyme calcineurin
• Furthermore, it can induce apoptosis and inhibit angiogenesis induced by VEGF
• It exerts potent immunosuppressive activity on T immune cells, and causes reversible inhibition of immunocompetent lymphocytes in the G0- and G1-phase of the cell cycle
• It also suppresses the hepatitis C virus replication in cultured hepatocytes

Specifications

General

Beilstein	3647785
CAS	59865-13-3
Chemical Name or Material	Cyclosporin A
EINECS Number	611-907-1
Formula Weight	1202.61
Health Hazard 1	H302-H350-H360FD
Health Hazard 2	<b>GHS H Statement</b><br />H361-H302<br /> Suspected of damaging fertility or the unborn child.<br />Harmful if swallowed.
Health Hazard 3	P201-P202-P264b-P270-P281-P301+P312-P308+P313-P330-P501c
IUPAC Name	30-ethyl-33-[(4E)-1-hydroxy-2-methylhex-4-en-1-yl]-1,4,7,10,12,15,19,25,28-nonamethyl-6,9,18,24-tetrakis(2-methylpropyl)-3,21-bis(propan-2-yl)-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontan-2,5,8,11,14,17,20,23,26,29,32-undecone
InChI Key	PMATZTZNYRCHOR-IMVLJIQENA-N
MDL Number	MFCD00274558
Melting Point	146°C to 151°C
Merck Index	14,2752
Molecular Formula	C62H111N11O12
PubChem CID	132274082
RTECS Number	GZ4120000
Recommended Storage	Store at -20°C
SMILES	CCC1NC(=O)C(C(O)C(C)C\C=C\C)N(C)C(=O)C(C(C)C)N(C)C(=O)C(CC(C)C)N(C)C(=O)C(CC(C)C)N(C)C(=O)C(C)NC(=O)C(C)NC(=O)C(CC(C)C)N(C)C(=O)C(NC(=O)C(CC(C)C)N(C)C(=O)CN(C)C1=O)C(C)C

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Thermo Fisher, J63191.03, Cyclosporin A, 99+%

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