Thermo Fisher, J67209.XF, Doxorubicin hydrochloride, 10 mg/ml in dH2O, sterilised

Name: Doxorubicin hydrochloride, 10 mg/ml in dH2O, sterilised
Brand: Thermo Fisher
SKU: J67209.XF

Quantity: 1 mL, Unit Size: Each, Doxorubicin hydrochloride is a DNA intercalator and powerful cytotoxic agent. Doxorubicin inhibits topoisomerase II which results in an increased and stabilized cleavable enzyme-DNA linked complex during DNA replication and subsequently prevents the ligation of the nucleotide strand after double-strand breakage. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refe

Catalog Number: J67209.XF

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Category

Hormones for Cell Culture

Pack Size1 mL

TagsCell Culture Media Antibiotics Supplements and Reagents Cell Culture Reagents Antibiotics and Supplements

CollectionsThermo Fisher Cell Culture Media & Supplements | Serum-Free, Chemically Defined Thermo Fisher Clinical Analyzers & Instruments for Diagnostic Labs Thermo Fisher General Lab Supplies for Daily Workflows — Nalgene, Nunc, Samco & Matrix

Description

Quantity: 1 mL
Unit Size: Each
General Description
• Doxorubicin hydrochloride, isolated from the bacterium Streptomyces peucetius, is an anthracycline antibiotic with antineoplastic activity and is related to daunorubicin
• It can intercalate between base pairs in the DNA helix preventing DNA replication
• It also inhibits nucleic acid synthesis and can induce apoptosis
• It can inhibit DNA topoisomerase II, resulting in an increased and stabilized cleavable enzyme-DNA linked complex during DNA replication, and prevents nucleotide strand ligation after double-strand breakage
• Doxorubicin hydrochloride forms oxygen free radicals that results in cytotoxicity and leads to the lipid peroxidation of cell membrane lipidsApplication
• This compound displays a fluorescent property allowing the measurement of drug efflux pump activity and examining the role of subcellular organelles (Golgi complex and lysosome) in the sequestration of drugs
• It has been used in cell viability assays
• It is used as a drug in polymeric PLGA-based microparticulate drug delivery and to develop in vitro doxorubicin-resistant HepG2 cells (HepG2-DR) and K562 cells (K562-DR)
• It is a substrate of the MRP1 transporter

Specifications

General

CAS	25316-40-9
Chemical Name or Material	Doxorubicin hydrochloride
EINECS Number	246-818-3
Health Hazard 1	H340-H350
Health Hazard 2	<b>GHS H Statement</b><br />H350<br /> May cause cancer.
Health Hazard 3	P201-P202-P281-P308+P313-P501c
IUPAC Name	hydrogen (8S,10S)-10-[(4-amino-5-hydroxy-6-methyloxan-2-yl)oxy]-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-5,7,8,9,10,12-hexahydrotetracene-5,12-dione chloride
InChI Key	MWWSFMDVAYGXBV-FGBJBKNOSA-N
MDL Number	MFCD00077757,MFCD00077757,MFCD00941448
Molecular Formula	C27H30ClNO11
Name Note	10mg/mL in DMSO, sterile filtered
PubChem CID	129626538
RTECS Number	QI9295900
Recommended Storage	Store at -20°C
SMILES	[H+].[Cl-].COC1=CC=CC2=C1C(=O)C1=C(O)C3=C(C[C@](O)(C[C@@H]3OC3CC(N)C(O)C(C)O3)C(=O)CO)C(O)=C1C2=O
Solubility Information	Soluble in water (50 mM),methanol,isotonic sodium chloride,and DMSO (>10mg/ml). Insoluble in chloroform,and ether.
Storage Note 1	-30° to -10°C
TSCA	No

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Thermo Fisher, J67209.XF, Doxorubicin hydrochloride, 10 mg/ml in dH2O, sterilised

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