Merck, 324890-5MG, E-64 Protease Inhibitor

Name: E-64 Protease Inhibitor
Brand: Merck
SKU: 324890-5MG

Size:5 mg, E-64 Protease Inhibitor, (2 R, 3 R)-3-(( S)-1-(4-Guanidinobutylamino)-4-methyl-1-oxopentan-2-ylcarbamoyl)oxirane-2-carboxylic acid, trans-Epoxysuccinyl-L-leucylamido(4-guanidino)butane, L- trans-3-Carboxyoxira, (2R, 3R)-3-((S)-1-(4-Guanidinobutylamino)-4-methyl-1-oxopentan-2-ylcarbamoyl)oxirane-2-carboxylic acid, trans-Epoxysuccinyl-L-leucylamido(4-guanidino)butane, L-trans-3-Carboxyoxiran-R, The E-64 Protease Inhibitor, also referenced under CAS 66701-25-5, controls the biological ac

Available Catalog Numbers

324890-100MG 324890-1GM 324890-1MG 324890-25MG 324890-500MG 324890-5MG

Catalog Number: 324890-5MG

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Category

Protease Inhibitors

Pack Size5 mg

CollectionsMerck Cell Culture Supplements & Reagents: Complete Solutions for Research & Bioproduction Merck Roche Life Science Products for PCR, RT‑PCR & Nucleic Acid Purification

Description

General description
Irreversible inhibitor of cysteine proteases. Interacts with the Sn subsites of proteases. Has no action on cysteine residues in other proteins. Inhibits activation-induced programmed cell death and restores defective immune responses in HIV⁺ donors. Specific active site titrant.
Biochem/physiol Actions
Cell permeable: no
Primary Target
cysteine proteases
Product does not compete with ATP.
Reversible: no
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.
Other Notes
Matsumoto, K., et al. 1999. Biopolymers51, 99.
Sarin, A., et al. 1994. J. Immunol.153, 862.
Sarin, A., et al. 1993. J. Exp. Med. 178, 1693.
Barrett, A.J. 1982. Biochem. J.201, 189.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)

Specifications

General

UNSPSC Code	12352200
NACRES	NA.77
MDL number	MFCD00080261
SMILES string	N([C@@H](CC(C)C)C(=O)NCCCCN\C(=N/[H])\N)C(=O)[C@@H]1O[C@H]1C(=O)O
InChI	1S/C15H27N5O5/c1-8(2)7-9(20-13(22)10-11(25-10)14(23)24)12(21)18-5-3-4-6-19-15(16)17/h8-11H,3-7H2,1-2H3,(H,18,21)(H,20,22)(H,23,24)(H4,16,17,19)/t9-,10+,11+/m0/s1
InChI key	LTLYEAJONXGNFG-HBNTYKKESA-N
description	RTECS - RR0390000
assay	≥98% (HPLC)
form	solid
manufacturer/tradename	Calbiochem®
storage condition	OK to freeze
color	white
solubility	water: 20 mg/mL
shipped in	ambient
storage temp.	−20°C
Quality Level	200

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Merck, 324890-5MG, E-64 Protease Inhibitor

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