Merck, D4010-10MG, 2′-Deoxyguanosine 5′-triphosphate sodium salt hydrate

Application
2′-Deoxyguanosine 5′-triphosphate sodium salt hydrate has been used:
as a component in a polymerase chain reaction (PCR) mixture for PCR product formation using AM-toxin primers
as an internal standard to improve the analytical performance of capillary electrophoresis (CE) analysis for the evaluation of the cleanup process
as a putative substrate in in vitro enzyme activity assay to incubate with nudix hydrolase 15 (NUDT15) protein for the evaluation of putative NUDT15 inhibitors

Biochem/physiol Actions
Deoxyguanosine 5′-triphosphate (dGTP), a purine deoxynucleotide, is a substrate of DNA polymerase(s) and reverse transcriptases. dGTP is useful to study the distribution, specificity, and kinetics of various nucleoside-triphosphatases (NTPase) and ribonucleotide reductases.