Merck, GNZ-0993-BP, Neu5Acα3GalNAcα-C3-PAA-biot

General description
BP-Series: Biotinylated Polymeric Probes
This series of glycoconjugate probes includes HOCH₂CH₂NH₃⁺-salts for acidic sugars. The affinity of these probes is 10² to 10⁵ times higher than that of the corresponding free sugars. The spacer-arm is normally –(CH₂)₃–, while the spacer arm for biotin is –(CH₂)₆–. The flexible polymer chain behaves as an additional spacer.

Used as a high molecular weight carrier, poly[N-(2-hydroxyethyl)acrylamide], abbreviated as PAA, has
low non-specific sorption, and is stable to chemical and proteolytic action.
Application
Glycoconjugates are used to study the functions of carbohydrates, carbohydrate-binding proteins in biological processes, and on the discovery of new carbohydrate-mediated interactions.
Preparation Note
Purity: synthetic ω-aminoalkyl glycosides used for coupling with the polymer have a purity of >95% (HPLC and ¹H-NMR)