Description
General description
Anti-cytokine antibodies occur frequently and are present in healthy individuals and patients with acquired immunodeficiency and autoimmune diseases. Cytokines offering protection against microbes can be targeted by cytokine autoantibodies, leading to life-threatening infections. Some infections associated with anti-cytokine antibodies include M. tuberculosis, Salmonella, S. aureus. E. coli, Histoplasma, and more. The presence of cytokine autoantibodies in autoimmune disease can influence disease severity and activity. These autoimmune diseases may include systemic lupus erythematosus, multiple sclerosis, Sjögren′s syndrome, rheumatoid arthritis, and acute respiratory distress syndrome.
Application
MILLIPLEX® Qualified assays undergo rigorous assay development, verification, and Quality Control testing to achieve optimal performance. Simultaneously analyze up to 23 analytes in human serum and plasma samples.
Analytes included: Anti-BAFF, Anti-G-CSF, Anti-IFNβ, Anti-IFNγ, Anti-IL-1α, Anti-IL-6, Anti IL 8, Anti-IL-10, Anti-IL-12p40, Anti-IL-15, Anti-IL-17A, Anti-IL-17F, Anti-IL-18, Anti-IL-22, Anti-TNFα, Anti-IFNα2, Anti-GM-CSF, Anti-IL-2, Anti-IL-3, Anti-IL-4, Anti-Osteopontin, Anti-PF4, and Anti-IFNψ
Note: This is a qualitative assay.
Assay Characteristics: Refer to kit protocol for assay cross-reactivity and precision.
Features and Benefits
Qualitative Detection: Provides reliable presence/absence determination of cytokine autoantibodies, supporting research classification and biomarker discovery studies.
Early Immune Response Detection: Capture IgM cytokine autoantibodies representing primary immune responses and early-stage autoimmune processes, enabling investigation of disease initiation and acute immune dysfunction.
Acute Phase Investigation: Monitor IgM autoantibodies during acute disease flares and initial immune system activation in research studies of autoimmune disease progression.
Comprehensive Immune Profiling: Combined use of IgG, IgM, and IgA panels provides complete temporal and functional assessment of cytokine autoantibody responses in research applications.
Legal Information
Luminex is a registered trademark of Luminex Corporation
MILLIPLEX is a registered trademark of Merck KGaA, Darmstadt, Germany
xMAP is a registered trademark of Luminex Corp
Disclaimer
For research use only. Not for use in diagnostic procedures.
Label License/Sticker for Assay Product:
By opening the packaging containing this Assay Product (which contains fluorescently labeled microsphere beads authorized by Luminex Corporation) or using this Assay Product in any manner, you are consenting and agreeing to be bound by the End User Terms and Conditions and the End User License Agreement available at http://support.diasorin.com/end-user-terms-and-conditions/. If you do not agree to all of the terms and conditions, you must promptly return this Assay Product for a full refund prior to using it in any manner.
