Merck, S6883-10MG, Substance P acetate salt hydrate

Name: Substance P acetate salt hydrate
Brand: Merck
SKU: S6883-10MG

Size:10 mg, ≥95% (HPLC), powder

Available Catalog Numbers

S6883-10MG S6883-1MG S6883-25MG

Catalog Number: S6883-10MG

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Category

SPE 96-Well Plates

Pack Size10 mg

CollectionsMerck Cell Culture Supplements & Reagents: Complete Solutions for Research & Bioproduction Merck Roche Life Science Products for PCR, RT‑PCR & Nucleic Acid Purification

Description

General description
Research area: Cell Signaling

Substance P is a member of the tachykinin family of peptides. It is encoded by the tachykinin precursor 1 (TAC1) gene mapped to human chromosome 7q21-q22. Substance P is a small peptide produced by macrophages, lymphocytes, eosinophils, dendritic cells and nerves. It is part of the neurokinin group.
Application
Substance P acetate salt hydrate has been:

used as a neurokinin 1 (NK1) receptor agonist for the activation of spinal nociceptive circuitry in mice
administered in central nucleus (ACE) in rat to study its positive reinforcing effects
used in competition binding assays
used as an inhibitor of myosin light chain kinase in isolated lymphatic vessels from rat

Biochem/physiol Actions
Substance P has proinflammatory effects on epithelial and immune cells. It has been associated with inflammatory diseases related to gastrointestinal and respiratory systems. Substance P modulates contractility of smooth muscles, transport of ions in the epithelium, vascular permeability and immune functions in the gut.
NK-1 agonist; potent vasodilator and hypotensive agent.
NK-1 agonist; potent vasodilator and hypotensive agent; induces salivation; increases capillary permeability; induces mast cell degranulation; putative neurotransmitter in sensory (pain) afferents.

Specifications

General

UNSPSC Code	12352200
PubChem Substance ID	24899725
NACRES	NA.32
Web Name Suffix Override	≥95% (HPLC), NK-1 agonist, powder
Beilstein/REAXYS Number	5153552
SMILES string	[H]O[H].CC(O)=O.CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]3CCCN3C(=O)[C@H](CCCCN)NC(=O)[C@@H]4CCCN4C(=O)[C@@H](N)CCCNC(N)=N)C(N)=O
InChI	1S/C63H98N18O13S.C2H4O2.H2O/c1-37(2)33-45(57(89)74-41(53(68)85)27-32-95-3)73-52(84)36-72-54(86)46(34-38-15-6-4-7-16-38)78-58(90)47(35-39-17-8-5-9-18-39)79-56(88)42(23-25-50(66)82)75-55(87)43(24-26-51(67)83)76-59(91)49-22-14-31-81(49)62(94)44(20-10-11-28-64)77-60(92)48-21-13-30-80(48)61(93)40(65)19-12-29-71-63(69)70;1-2(3)4;/h4-9,15-18,37,40-49H,10-14,19-36,64-65H2,1-3H3,(H2,66,82)(H2,67,83)(H2,68,85)(H,72,86)(H,73,84)(H,74,89)(H,75,87)(H,76,91)(H,77,92)(H,78,90)(H,79,88)(H4,69,70,71);1H3,(H,3,4);1H2/t40-,41-,42-,43-,44-,45-,46?,47-,48-,49-;;/m0../s1
InChI key	VHKFRLDSEZYWAC-CIYRQLMPSA-N
assay	≥95% (HPLC)
form	powder
mol wt	1348 Da by calculation (Average Mass)

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Merck, S6883-10MG, Substance P acetate salt hydrate

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