Merck, S6883-1MG, Substance P acetate salt hydrate

Name: Substance P acetate salt hydrate
Brand: Merck
SKU: S6883-1MG

Size:1 mg, ≥95% (HPLC), powder

Available Catalog Numbers

S6883-10MG S6883-1MG S6883-25MG

Catalog Number: S6883-1MG

Pricing

Send an RFQ.

View RFQ List

Category

SPE 96-Well Plates

Pack Size1 mg

CollectionsMerck Cell Culture Supplements & Reagents: Complete Solutions for Research & Bioproduction Merck Roche Life Science Products for PCR, RT‑PCR & Nucleic Acid Purification

Description

General description
Research area: Cell Signaling

Substance P is a member of the tachykinin family of peptides. It is encoded by the tachykinin precursor 1 (TAC1) gene mapped to human chromosome 7q21-q22. Substance P is a small peptide produced by macrophages, lymphocytes, eosinophils, dendritic cells and nerves. It is part of the neurokinin group.
Application
Substance P acetate salt hydrate has been:

used as a neurokinin 1 (NK1) receptor agonist for the activation of spinal nociceptive circuitry in mice
administered in central nucleus (ACE) in rat to study its positive reinforcing effects
used in competition binding assays
used as an inhibitor of myosin light chain kinase in isolated lymphatic vessels from rat

Biochem/physiol Actions
Substance P has proinflammatory effects on epithelial and immune cells. It has been associated with inflammatory diseases related to gastrointestinal and respiratory systems. Substance P modulates contractility of smooth muscles, transport of ions in the epithelium, vascular permeability and immune functions in the gut.
NK-1 agonist; potent vasodilator and hypotensive agent.
NK-1 agonist; potent vasodilator and hypotensive agent; induces salivation; increases capillary permeability; induces mast cell degranulation; putative neurotransmitter in sensory (pain) afferents.

Specifications

General

UNSPSC Code	12352200
PubChem Substance ID	24899725
NACRES	NA.32
Web Name Suffix Override	≥95% (HPLC), NK-1 agonist, powder
Beilstein/REAXYS Number	5153552
SMILES string	[H]O[H].CC(O)=O.CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]3CCCN3C(=O)[C@H](CCCCN)NC(=O)[C@@H]4CCCN4C(=O)[C@@H](N)CCCNC(N)=N)C(N)=O
InChI	1S/C63H98N18O13S.C2H4O2.H2O/c1-37(2)33-45(57(89)74-41(53(68)85)27-32-95-3)73-52(84)36-72-54(86)46(34-38-15-6-4-7-16-38)78-58(90)47(35-39-17-8-5-9-18-39)79-56(88)42(23-25-50(66)82)75-55(87)43(24-26-51(67)83)76-59(91)49-22-14-31-81(49)62(94)44(20-10-11-28-64)77-60(92)48-21-13-30-80(48)61(93)40(65)19-12-29-71-63(69)70;1-2(3)4;/h4-9,15-18,37,40-49H,10-14,19-36,64-65H2,1-3H3,(H2,66,82)(H2,67,83)(H2,68,85)(H,72,86)(H,73,84)(H,74,89)(H,75,87)(H,76,91)(H,77,92)(H,78,90)(H,79,88)(H4,69,70,71);1H3,(H,3,4);1H2/t40-,41-,42-,43-,44-,45-,46?,47-,48-,49-;;/m0../s1
InChI key	VHKFRLDSEZYWAC-CIYRQLMPSA-N
assay	≥95% (HPLC)
form	powder
mol wt	1348 Da by calculation (Average Mass)

Ordering

Notice

Unless otherwise stated, the minimum order amount is USD 1,000.
For orders below USD 1,000, an additional handling fee may apply, or we may arrange local delivery / local handover where available.
All quotations are subject to final confirmation, including product availability, lead time, batch information, shipping cost, and applicable export or handling requirements.
For quotation requests, please send an RFQ from website or contact:

[email protected]

Please send inquiries directly to us in the “To” field. Emails sent via BCC, mass mailing, or with unrelated recipients may be automatically filtered and will not be processed.

Merck, S6883-1MG, Substance P acetate salt hydrate

Send an RFQ.

General

Notice

More from Merck.

Superspher® 60 RP-8 LiChroCART™ 250-4

Superspher® 60 RP-select B LiChroCART™ 250-4

Aluminum chloride hexahydrate

Ninhydrin Reagent

More from Merck.

Superspher® 60 RP-8 LiChroCART™ 250-4

Superspher® 60 RP-select B LiChroCART™ 250-4

Aluminum chloride hexahydrate

Ninhydrin Reagent