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The least expensive chromatography resin is not the resin with the lowest price per liter. It is the resin–process combination that delivers the lowest cost per accepted batch or per gram of released…
Moving from batch chromatography to periodic counter-current chromatography (PCC) changes the resin-selection question. The best batch resin is not automatically the best continuous resin: the rankin…
A conventional IgG platform is a useful starting hypothesis—not a transferable process. Bispecific antibodies, antibody–drug conjugates (ADCs), Fab/scFv fragments and Fc-fusion proteins can differ in…
Mixed-mode chromatography can sometimes collapse two purification operations into one—but only when its additional selectivity survives the real feed, recovery target, hydraulic limits and lifecycle…
Ion exchange chromatography (IEX) is often described as a choice between CEX and AEX. In practice, the useful question is more specific: which charge interaction, operating mode and buffer window wil…
This article proposes a practical benchmark for modern antibody manufacturing. It distinguishes peer-reviewed studies, a biopharma-authored industry case study, regulatory guidance and supplier speci…
Selecting a chromatography resin is not a catalog-matching exercise. It is a separation-design problem: the target molecule, the impurities that must be removed, the operating window and the bioproce…
Cytiva part number AB1USV47PH4 is a 10-inch Pall™ Pegasus™ SV4 virus-removal cartridge: a direct-flow, nominal 20 nm, hydrophilic modified-PVDF filter with a Pall Code 7 bayonet/fin connection, two s…
