Merck, 48-630MAG, MILLIPLEX® NF-κB Signaling Panel

General description
The NFκB pathway plays a central role in regulating immune response, inflammation, cell survival, and proliferation. This panel includes key phosphorylated and total proteins involved in NFκB signaling, such as IκBα, IKKα/β, and NFκB itself, along with upstream and downstream effectors like TNFR1 and c-Myc. Quantifying these analytes provides insights into cellular responses to stress, cytokines, and other stimuli in rodent models.
Application
MILLIPLEX® Qualified assays undergo rigorous assay development, verification, and Quality Control testing to achieve optimal performance. Simultaneously analyze 6 analytes in human cell lysate samples.

Analytes Included: c-Myc, FADD (Ser194), IκBα (Ser32), IKKα/β (Ser177/Ser181), NFκB (Ser536), TNFR1

Assay Characteristics: Refer to the assay protocol for details on cross-reactivity, buffer compatibility, lysate control, and recommended loading control (MAPmate™Control Assays).
Features and Benefits
Measures six key signaling proteins involved in the NFκB pathway in cell or tissue lysates
Supports detailed analysis of phosphorylation events and pathway activation
Ideal for studies focused on inflammation, immune response, and cellular stress signaling
High sensitivity and reproducibility for reliable intracellular protein quantification
Offers a high-throughput alternative to Western blotting, reducing assay time and sample requirements while improving data consistency

Legal Information
Luminex is a registered trademark of Luminex Corp
MAPMATE is a trademark of Merck KGaA, Darmstadt, Germany
MILLIPLEX is a registered trademark of Merck KGaA, Darmstadt, Germany
xMAP is a registered trademark of Luminex Corp
Disclaimer
For research use only. Not for use in diagnostic procedures.

Label License/Sticker for Assay Product:

By opening the packaging containing this Assay Product (which contains fluorescently labeled microsphere beads authorized by Luminex Corporation) or using this Assay Product in any manner, you are consenting and agreeing to be bound by the End User Terms and Conditions and the End User License Agreement available at http://support.diasorin.com/end-user-terms-and-conditions/. If you do not agree to all of the terms and conditions, you must promptly return this Assay Product for a full refund prior to using it in any manner.