Description
General description
BAK and BAX promote mitochondrial outer membrane permeabilization, while BCL-2, BCL-W, BCL-XL, and MCL-1 inhibit apoptosis. Together, these proteins regulate the intrinsic apoptotic pathway and determine cell fate under stress conditions.
Application
MILLIPLEX® Qualified assays undergo rigorous assay development, verification, and Quality Control testing to achieve optimal performance. Simultaneously analyze 6 analytes in human cell lysate samples.
Analytes Included: BAD (pS112), BAD (Total), BAX, Bcl-xL/BAD, BIM, Mcl-1/BIM
Assay Characteristics: Refer to the assay protocol for details on cross-reactivity, buffer compatibility, lysate control, and recommended loading control (MAPmate™ Control Assays).
Features and Benefits
Simultaneous detection of 6 key Bcl-2 family proteins
Enables profiling of pro- and anti-apoptotic markers
Supports studies on mitochondrial-mediated apoptosis
Multiplex format conserves sample and increases throughput
Verified for use with human cell lysates
Legal Information
Luminex is a registered trademark of Luminex Corp
MAPMATE is a trademark of Merck KGaA, Darmstadt, Germany
MILLIPLEX is a registered trademark of Merck KGaA, Darmstadt, Germany
xMAP is a registered trademark of Luminex Corp
Disclaimer
For research use only. Not for use in diagnostic procedures.
Label License/Sticker for Assay Product:
By opening the packaging containing this Assay Product (which contains fluorescently labeled microsphere beads authorized by Luminex Corporation) or using this Assay Product in any manner, you are consenting and agreeing to be bound by the End User Terms and Conditions and the End User License Agreement available at http://support.diasorin.com/end-user-terms-and-conditions/. If you do not agree to all of the terms and conditions, you must promptly return this Assay Product for a full refund prior to using it in any manner.